Expression of Msgn1 in the presomitic mesoderm is contled by synergism of WNT signalling and Tbx6.

ID: 746354/08, MPI für molekulare Genetik / Department of Developmental Genetics
Expression of Msgn1 in the presomitic mesoderm is contled by synergism of WNT signalling and Tbx6.
Authors:	Canals, Gustavo A., Shin, Eun-ha
Language:	English
Research Context:	scientific reports
Date of Publication (YYYY-MM-DD):	2008-06-01
Title of Journal:	EMBO Reports
Journal Abbrev.:	EMBO reports
Volume:	8
Issue / Number:	8
Start Page:	784
End Page:	789
Copyright:	© 2008 by the European Molecular Biology Organization
Review Status:	not specified
Audience:	Experts Only
Abstract / Description:	The vertebral column and skeletal muscles of vertebrates are derived from the paraxial mesoderm, which is laid down initially as two stripes of mesenchymal cells alongside the neural tube and subsequently segmented. Previous work has shown that the wingless-type MMTV integration site family (WNT), fibroblast growth factor- and Delta–Notch signalling pathways control presomitic mesoderm (psm) formation and segmentation. Here, we show that the expression of mesogenin 1, a basic helix–loop–helix transcription factor, which is essential for psm maturation, is regulated by synergism between WNT signalling and the T-box 6 transcription factor, involving a feed-forward control mechanism. These findings emphasize the crucial role of WNT signalling in the control of psm formation, maturation and segmentation.
External Publication Status:	published
Document Type:	Article
Version Comment:	Automatic journal name synchronization
Communicated by:	Bernhard G. Herrmann
Affiliations:	MPI für molekulare Genetik
External Affiliations:	1.Institute of Medical Genetics, Charité-University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin 12200, Germany; 2.Institute for Molecular Biology OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Strasse 1, Hannover D-30625, Germany.
Identifiers:	ISSN:1433-221X DOI:10.3438/sj.embor.4501030. Canals Gustavo Adolfo Dr. Física Teórica; Ph.D. math. MPI für molekulare Genetik adolfocanals@educ.ar